Lectin Immunoassay for Macrophage-activating Factor (Gc-MAF) Produced by Deglycosylation of Gc-Globulin: Evidence for Noninducible Generation of Gc-MAF
نویسندگان
چکیده
منابع مشابه
Lectin immunoassay for macrophage-activating factor (Gc-MAF) produced by deglycosylation of Gc-globulin: evidence for noninducible generation of Gc-MAF.
The vitamin D-binding protein, also known as groupspecific component (Gc) or Gc-globulin, is a 51.2-kDa polymorphic protein of the a2-macroglobulin fraction of human plasma (1 ). In human population, three common alleles (Gc1f, Gc1s, and Gc2) and .120 rare variant alleles have been classified by isoelectric focusing (2 ). Gc1f and Gc1s contain sialic acid residues, whereas Gc2 does not (2 ). Gc...
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This doctoral thesis is based on seven previously published papers and reports on the role of the actin-scavenger Gc-globulin in acute and chronic liver diseases. Gc-globulin is synthesized in the liver and is a multifunctional protein; however, its main physiologic function is presumably actin binding and actin scavenging. Actin is a major cellular protein released during cell necrosis that ma...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2000
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/46.3.412